Major parasitic zoonosis, hydatidosis is a public health problem, with the trend of recurrence and mortality at all negligible, causing great suffering to patients. Purpose of the study: to establish how the molecules used to chimio-prevent of hydatidosis influence plasma levels of enzymes. Materials and methods: there have been taken in the study 30 animals (lambs aged 12 months), which were infested with oncospheres of E. granulosus. To determine plasma levels of enzymes is harvested from blood samples on days 0, 30 and 60 of the experiment. Results and discussions: The plasma ASAT was approximately constant at all lots of lambs. In determining the plasma ALAT, the negative group differences between first and last measurement were statistically significant (p = 0.0053). Treatment with albendazole induced statistical variations between the first and last harvest index "p" is 0.0109. Evolutionary dynamics of GGT level in experimental groups of animals was characterized by fluctuations which showed statistical differences for some of the comparison analysis, as in the case group negative value index "p" was 0.0162 (harvested 1 - 3) , the positive group index "p" was p = 0.0400 (1 - 3), the group treated with albendazole, the index "p" was 0.0122 (1 - 2) and 0.0107 (1 - 3). PAL fluctuation recorded and analyzed according to the comparative experimental time has highlighted the significant differences from a statistical viewpoint. Conclusions: Exploration of liver medicine is to represent a biochemical exploration of the most common because this organ plays a central role in energy metabolism and mechanisms of detoxification of the body.